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Related Experiment Videos

Effects of selenium on polymorphonuclear leukocyte function in goats.

E S Aziz, P H Klesius, J C Frandsen

    American Journal of Veterinary Research
    |September 1, 1984
    PubMed
    Summary

    Selenium deficiency impairs goat polymorphonuclear neutrophil (PMN) function, affecting immune responses. Supplementation with selenium enhances PMN activity and glutathione peroxidase levels, crucial for immune health.

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    Area of Science:

    • Immunology
    • Nutritional Science
    • Veterinary Medicine

    Background:

    • Polymorphonuclear neutrophils (PMN) are critical immune cells.
    • Selenium is an essential trace element vital for immune function.
    • Nutritional status significantly impacts immune cell activity.

    Purpose of the Study:

    • To investigate the effect of selenium deficiency on goat PMN function.
    • To assess the impact of selenium supplementation on PMN activity.
    • To correlate PMN function with glutathione peroxidase (GPx) levels.

    Main Methods:

    • Assessed random migration and leukotaxis of goat PMN.
    • Measured phagocytosis of opsonized zymosan via chemiluminescence.
    • Analyzed blood, serum, and intracellular GPx activities.

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    Main Results:

    • Selenium-deficient diets severely depressed goat PMN functions.
    • In vitro selenium incubation enhanced PMN function.
    • In vivo selenium administration increased PMN activity.
    • PMN function changes correlated with GPx activity alterations.

    Conclusions:

    • Selenium inadequacy in goats leads to reduced PMN function.
    • Glutathione peroxidase levels are physiologically linked to PMN function.
    • Dietary selenium is crucial for maintaining robust immune cell activity in goats.