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Dopamine effect on bronchomotor tone in vivo
The American Review of Respiratory Disease
|November 1, 1984
Summary
Dopamine did not affect pulmonary resistance but did reduce histamine-induced bronchoconstriction in both normal and asthmatic subjects. This suggests dopamine has a beneficial effect during asthma attacks.
Area of Science:
- Pulmonary medicine
- Pharmacology
Background:
- Asthma is characterized by bronchoconstriction.
- The role of dopamine in asthma pathophysiology is not fully understood.
Purpose of the Study:
- To investigate the effects of dopamine on pulmonary resistance and histamine-induced bronchoconstriction.
Main Methods:
- Dopamine was administered via inhalation and infusion to normal and asthmatic subjects.
- Pulmonary resistance and histamine-induced bronchoconstriction were measured.
Main Results:
- Dopamine did not alter baseline pulmonary resistance.
- Dopamine significantly attenuated histamine-induced bronchoconstriction in all subjects.
Conclusions:
- Dopamine may have a protective role in asthma.
- Endogenous dopamine release during an asthma attack could be beneficial.