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Related Experiment Videos

Transient visual obscurations with elevated optic discs.

A A Sadun, J N Currie, S Lessell

    Annals of Neurology
    |October 1, 1984
    PubMed
    Summary
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    Transient vision loss, similar to papilledema, can occur from optic nerve head ischemia due to elevated tissue pressure from various causes, not just increased intracranial pressure.

    Area of Science:

    • Ophthalmology
    • Neurology
    • Vascular Biology

    Background:

    • Transient obscurations of vision (TOV) are often associated with papilledema, a condition linked to increased intracranial pressure.
    • The precise pathogenesis of TOV in papilledema remains debated.
    • Understanding TOV mechanisms is crucial for diagnosing and managing optic nerve head disorders.

    Observation:

    • Four cases of TOV were observed, clinically mimicking papilledema.
    • These visual disturbances occurred in patients with elevated optic discs from non-intracranial pressure-related causes.
    • The patients experienced transient episodes of vision loss.

    Findings:

    • The primary mechanism identified for TOV was transient ischemia of the optic nerve head.
    • Increased optic nerve head tissue pressure, caused by axonal swelling, intraneural masses, or interstitial fluid influx, was implicated.

    Related Experiment Videos

  • Reduced perfusion pressure in optic nerve head vasculature, exacerbated by minor blood pressure fluctuations, leads to ischemic events.

    • Implications:

    • This suggests that optic nerve head ischemia due to elevated tissue pressure is a common mechanism for TOV, irrespective of the cause of optic disc elevation.
    • The findings broaden the understanding of TOV pathogenesis beyond papilledema.
    • This may lead to revised diagnostic approaches for patients presenting with transient visual obscurations and optic disc edema.