Related Experiment Videos
Abdominal aortic cross-clamping. Metabolic and hemodynamic consequences
Archives of Surgery (Chicago, Ill. : 1960)
|November 1, 1984
Summary
An oxygen debt develops during abdominal aortic cross-clamping, but does not influence hemodynamic changes post-procedure. Higher narcotic doses during anesthesia did not affect the metabolic rate increase after unclamping.
Area of Science:
- Anesthesiology
- Cardiovascular Surgery
- Metabolic Physiology
Background:
- Abdominal aortic cross-clamping can induce hemodynamic changes.
- The potential development of an oxygen debt during this procedure is not fully understood.
Purpose of the Study:
- To investigate if an oxygen debt develops during abdominal aortic cross-clamping.
- To determine if this oxygen debt correlates with observed hemodynamic changes post-procedure.
- To assess the impact of varying morphine sulfate dosages on oxygen debt and metabolic response.
Main Methods:
- Three groups of patients received different dosages of morphine sulfate during anesthetic induction.
- Oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured before, during, and after abdominal aortic cross-clamping.
- Hemodynamic and biochemical parameters were also monitored.
Main Results:
- VO2 and VCO2 decreased during cross-clamping in all groups, indicating oxygen debt.
- The greatest increase in VO2 post-unclamping occurred in the highest morphine dose group (Group 3).
- Metabolic changes were not paralleled by hemodynamic or temperature alterations.
Conclusions:
- Oxygen debt develops during abdominal aortic cross-clamping but does not explain post-unclamping hemodynamic changes.
- Higher intraoperative narcotic dosage did not attenuate the post-unclamping increase in metabolic rate.