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Total plasma apo E and high density lipoprotein apo E in survivors of myocardial infarction
Insights
Myocardial infarction survivors show altered lipoprotein profiles, with higher LDL-C and lower HDL-C, even with normal total lipids. This suggests underlying apoprotein distribution abnormalities contribute to atherosclerosis.
Area of Science:
- Cardiovascular Medicine
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Myocardial infarction (MI) survivors often exhibit dyslipidemia.
- Apoprotein E (apo E) plays a crucial role in lipoprotein metabolism and reverse cholesterol transport.
Purpose of the Study:
- To investigate the distribution and concentration of apoprotein E (apo E) in normolipidemic male survivors of myocardial infarction.
- To compare lipoprotein and apoprotein profiles between MI survivors and control subjects.
Main Methods:
- Quantification of total plasma apo E and high-density lipoprotein associated apo E (HDL-E) in 40 MI survivors and 40 controls.
- Measurement of lipid parameters including LDL-C, HDL-C, and apoproteins apo B and apo A-I.
Main Results:
- MI survivors had significantly higher LDL-C, Lp(a), and apo B, and lower HDL-C and apo A-I compared to controls.
- Total plasma apo E levels were comparable between groups.
- Survivors showed significantly lower HDL-E and a reduced HDL-E/apo A-I ratio.
Conclusions:
- Normolipidemic MI survivors display distinct lipoprotein and apoprotein abnormalities.
- Altered distribution of apo E, particularly within HDL particles, may contribute to the pathophysiology of atherosclerosis despite normal overall lipid levels.
Abstract:
Total apo E in plasma and the amount of apo E-HDL were measured in 40 normolipidemic male survivors of myocardial infarction and in 40 controls. LDL-C, Lp(a) and apo B were significantly higher and HDL-C and apo A-I were significantly lower in survivors than in controls. Total plasma apo E did not differ between patients and controls, but HDL-E and the ratio HDL-E/apo A-I were lower in survivors. The data support the view that atherosclerotic patients are often characterized by abnormalities in the concentration and distribution of lipoproteins as well as of apoproteins, even in the presence of normal total plasma lipids.