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n-Hexane metabolism in occupationally exposed workers.

A Mutti, M Falzoi, S Lucertini

    British Journal of Industrial Medicine
    |November 1, 1984
    PubMed
    Summary

    Workers exposed to n-hexane showed significant lung uptake and excretion. Urinary 2,5-hexanedione levels provided a reliable estimate of n-hexane exposure in shoe factory workers.

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    Area of Science:

    • Occupational Health
    • Toxicology
    • Environmental Exposure

    Background:

    • n-Hexane is a common industrial solvent with potential health risks.
    • Understanding n-hexane's pharmacokinetic behavior in workers is crucial for exposure assessment.

    Purpose of the Study:

    • To quantify lung uptake and excretion of n-hexane in shoe factory workers.
    • To identify and measure n-hexane metabolites in urine for exposure estimation.

    Main Methods:

    • Collected simultaneous inhaled and alveolar air samples using Rhan-Otis valves and personal samplers.
    • Monitored alveolar excretion post-exposure and analyzed urinary metabolites (2,5-hexanedione) using capillary GC/MS.
    • Calculated uptake based on lung ventilation, retention coefficient, and environmental concentrations.

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    Main Results:

    • Alveolar retention of n-hexane was approximately 25% of inhaled amounts, with lung uptake around 17%.
    • Post-exposure alveolar excretion accounted for about 10% of total uptake.
    • Urinary 2,5-hexanedione concentrations correlated with airborne n-hexane levels, with ~3 mg/g creatinine indicating ~50 ppm exposure.

    Conclusions:

    • Lung uptake and excretion dynamics of n-hexane were characterized in an occupational setting.
    • Urinary 2,5-hexanedione is a valuable biomarker for estimating n-hexane exposure in workers.