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Dissociated vertical deviation: evidence of abnormal visual pathway projection.
The British Journal of Ophthalmology
|November 1, 1984
Summary
Patients with dissociated vertical deviation exhibit abnormal visual evoked responses, suggesting potential optic nerve pathway abnormalities. This finding was consistent regardless of visual acuity or amblyopia.
Area of Science:
- Neuroscience
- Ophthalmology
- Visual Science
Background:
- Abnormal visual evoked responses (VERs) indicate optic nerve fiber abnormalities in albinism.
- Dissociated vertical deviation (DVD) is characterized by anomalous nystagmoid movements.
Purpose of the Study:
- To investigate if patients with dissociated vertical deviation (DVD) show abnormal visual evoked responses, similar to albinos.
- To explore potential optic nerve pathway abnormalities in individuals with DVD.
Main Methods:
- Utilized visually evoked potentials (VEPs) to assess visual pathway function.
- Compared VEPs in patients with unilateral/alternating DVD, congenital esotropia without DVD, and normal subjects.
Main Results:
- A high incidence of abnormal VEPs was observed in patients with DVD.
- VEPs showed a marked increase in latency for all DVD patients.
- Recordings from control groups (congenital esotropia without DVD, normal subjects) were normal.
Conclusions:
- Suggests possible abnormalities in optic nerve fiber projections in patients with DVD.
- Increased VEP latency in DVD patients indicates potential visual pathway dysfunction.
- These VEP abnormalities in DVD are independent of visual acuity or amblyopia.