Intracranial plasmacytoma associated with multiple myeloma

Area of Science:

• Neurology
• Oncology
• Ophthalmology

Background:

• Multiple myeloma is a plasma cell malignancy.
• Intracranial plasmacytomas are rare complications of multiple myeloma.
• Cerebral compression symptoms can mimic other conditions.

Observation:

• A 58-year-old man with multiple myeloma presented with occipital pressure, blurred vision, and increased bone pain.
• Funduscopic examination showed papilledema, tortuous retinal veins, and hemorrhages, suggesting hyperviscosity syndrome.
• Computerized tomography revealed an intracranial plasmacytoma causing the papilledema.

Findings:

• The patient was treated with Cobalt 60 beam therapy and vincristine.
• Within seven weeks, the intracranial tumor significantly regressed.
• This case highlights an uncommon presentation of symptomatic cerebral compression.

Implications:

• Early diagnosis and multimodal treatment are crucial for managing intracranial plasmacytomas.
• This case underscores the importance of considering rare neurological complications in multiple myeloma patients.
• Effective treatment can lead to significant tumor reduction and symptom improvement.