Hollenhorst plaques
Related Experiment Video
Updated: Nov 5, 2026
06:02
Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model
Published on: July 26, 2011
Journal of the American Optometric Association
|April 1, 1978
Insights
Hollenhorst plaques in the eye
Area of Science:
- Ophthalmology and Vascular Medicine
Background:
- Hollenhorst plaques are cholesterol emboli found in retinal arteries.
- Their presence in asymptomatic individuals suggests underlying systemic atherosclerosis.
Purpose of the Study:
- To highlight the significance of detecting Hollenhorst plaques in asymptomatic patients.
- To recommend medical evaluation and risk factor management for these individuals.
Main Methods:
- Retinal examination for the presence of Hollenhorst plaques.
Main Results:
- Detection of Hollenhorst plaques in asymptomatic patients indicates atherosclerotic disease.
Conclusions:
- Asymptomatic patients with Hollenhorst plaques require prompt medical assessment.
- Management should focus on addressing atherosclerotic risk factors to prevent future cardiovascular events.
Abstract:
Detection of Hollenhorst plaques in the retinal circulation of the asymptomatic patient should be considered to be indicative of atherosclerotic disease. Such patients should be referred for medical evaluation and amelioration of risk factors.
Related Concept Videos
03:03Amyloid Fibrils
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
01:23Alzheimer Disease ll: Pathophysiology
Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
01:21Huntington Disease l: Introduction
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...