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Total deficiency of corticosteroid-binding globulin
Clinical Endocrinology
|November 1, 1984
Summary
This study reports the first cases of complete cortisol-binding-globulin (CBG) deficiency in siblings. This benign condition appears to be inherited as an autosomal trait, either codominant or recessive.
Area of Science:
- Endocrinology
- Human Genetics
- Biochemistry
Background:
- Cortisol-binding-globulin (CBG) plays a crucial role in regulating the bioavailability of cortisol in plasma.
- Previous literature has not extensively documented complete deficiencies of CBG.
- Understanding CBG levels is important for interpreting cortisol measurements and diagnosing adrenal disorders.