Morphological changes of the isocortex in morbus Parkinson

An increasing number of pyramidal cells in the third layer of the human neocortex with pigment-filled expansions of their proximal axon is correlated with advancing age. Comparison between cases of morbus Parkinson and an age-matched control group reveals that the number of these pathologically altered pyramidal cells is significantly higher in cases of morbus Parkinson than in controls.