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Related Experiment Videos

Patch testing with colophony.

S Fregert, B Gruvberger

    Contact Dermatitis
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Neutral components of colophony (rosin) cause more allergic reactions than colophony itself during patch testing. A 60% concentration of colophony is recommended for routine testing to improve detection of these allergies.

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    Area of Science:

    • Dermatology
    • Allergology
    • Chemical analysis

    Background:

    • Colophony (rosin) is a common contact allergen.
    • Identifying specific allergenic components is crucial for accurate diagnosis.

    Purpose of the Study:

    • To evaluate the diagnostic potential of colophony fractions in patch testing.
    • To determine optimal concentrations for detecting colophony allergy.

    Main Methods:

    • Colophony was fractionated into acidic and neutral components.
    • Patch testing was performed using these fractions and whole colophony.
    • Reaction frequencies were compared.

    Main Results:

    • Neutral colophony fractions elicited positive reactions with 40% higher frequency than whole colophony.

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  • Whole colophony (20% w/w in petrolatum) showed lower sensitivity.

    • Conclusions:

    • Neutral components are key allergens in colophony.
    • A 60% concentration of colophony in petrolatum is suggested for routine patch testing to enhance diagnostic accuracy.