Enterosorption in prolonging old animal lifespan

Area of Science:

• Gerontology and Regenerative Medicine
• Toxicology and Pharmacology

Background:

• Aging is associated with progressive decline in physiological functions and increased susceptibility to disease.
• Enterosorption, a method of internal detoxification, has shown potential in mitigating age-related changes.

Purpose of the Study:

• To investigate the impact of repeated enterosorption courses on lifespan and functional/metabolic indices in aged rats.
• To evaluate the effects of enterosorption on age-related structural and biochemical alterations in key organs.

Main Methods:

• Administration of enterosorbents to 28-month-old Wistar rats.
• Assessment of mean and maximal lifespan.
• Histological and ultrastructural analysis of liver, kidneys, myocardium, intestines, and pancreas.
• Measurement of cytochrome P-450, cholesterol, triglycerides, and RNA/protein biosynthesis.

Main Results:

• Significant increases in mean and maximal lifespan were observed with specific enterosorption regimens.
• Reduced age-related structural and ultrastructural changes in multiple organs compared to controls.
• Decreased pentobarbital-induced sleep duration and lower levels of cytochrome P-450, cholesterol, and triglycerides.
• Enhanced RNA and protein biosynthesis in the liver, kidneys, and adrenals of treated rats.

Conclusions:

• Enterosorption can extend lifespan and ameliorate age-related physiological decline in aged rats.
• The intervention positively impacts metabolic profiles and cellular biosynthetic capacity.
• Enterosorption demonstrates potential as a therapeutic strategy for promoting healthy aging.