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Related Experiment Videos

Candidiasis-induced esophageal strictures.

F P Agha

    Gastrointestinal Radiology
    |January 1, 1984
    PubMed
    Summary

    Esophageal candidiasis can lead to severe fibrosed strictures in immunocompromised patients, even with antifungal treatment. These progressive esophageal strictures may necessitate surgical intervention for esophageal substitution.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Immunology

    Background:

    • Esophageal candidiasis is a common opportunistic infection, particularly in immunocompromised individuals.
    • Broad-spectrum antibiotic use can disrupt the normal flora, increasing the risk of fungal overgrowth.

    Observation:

    • Two cases of esophageal candidiasis progressing to severe, fibrosed strictures are presented.
    • Both patients had underlying immunodeficiencies and received prolonged antibiotic therapy for sepsis.

    Findings:

    • The esophageal strictures were progressive and refractory to antifungal medications and endoscopic dilations.
    • Aggressive antifungal therapy and dilatations failed to resolve the fibrosed strictures.

    Implications:

    • Severe esophageal candidiasis can result in irreversible esophageal strictures requiring advanced surgical management.
    • Visceral esophageal substitution was necessary for definitive treatment in these refractory cases.

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