Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Additive by additive variance with inbreeding and linkage.

C C Cockerham

    Genetics
    |October 1, 1984
    PubMed
    Summary

    This study developed methods for calculating two-locus coancestries, crucial for understanding genetic variance in quantitative traits. Ignoring genetic linkage in these calculations introduces minimal error, especially with increased inbreeding.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Random and fixed effects in plant genetics.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Covariances of relatives and selection response in generations of selfing from an outcrossed base population.

    TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
    Same author

    Design III with marker loci.

    Genetics·1996
    Same author

    Further observations on the evolution of additive genetic variation with mutation.

    Theoretical population biology·1994
    Same author

    Mutation models and quantitative genetic variation.

    Genetics·1993
    Same author

    Multiplicative vs. arbitrary gene action in heterosis.

    Genetics·1992

    Area of Science:

    • Quantitative genetics
    • Population genetics
    • Statistical genetics

    Background:

    • Two-locus coancestries are essential for estimating the additive by additive genetic variance component.
    • Understanding these coancestries is vital for accurate genetic analysis in breeding and evolution.

    Purpose of the Study:

    • To formulate general expressions for two-locus coancestries, incorporating genetic linkage.
    • To evaluate the impact of linkage on coancestry calculations across various relatedness scenarios.

    Main Methods:

    • Developed general formulas for two-locus coancestries using probabilities of identity by descent.
    • Derived explicit expressions for different relative types, including self-fertilized, outbred, and sibs.
    • Analyzed the effect of genetic linkage on coancestry coefficients.

    Main Results:

    • Explicit expressions for two-locus coancestries were derived, accounting for genetic linkage.
    • The influence of linkage on coancestry diminishes significantly with increasing inbreeding and relatedness.
    • The relative effect of linkage decreases rapidly as inbreeding and relatedness increase.

    Conclusions:

    • Ignoring genetic linkage in two-locus coancestry calculations likely results in small errors.
    • This finding is particularly relevant for estimating genetic variances and predicting selection response in self-fertilizing populations.

    Related Experiment Videos