Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Increased serum IgG levels in essential hypertension.

P Suryaprabha, T Padma, U B Rao

    Immunology Letters
    |January 1, 1984
    PubMed
    Summary

    Serum immunoglobulin G (IgG) levels are significantly higher in essential hypertension patients compared to healthy individuals. This suggests a potential role for immune system responses in the development of hypertension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Risk conferred by tagged SNPs of AGT gene in causing susceptibility to essential hypertension.

    Clinical and experimental hypertension (New York, N.Y. : 1993)·2014
    Same author

    Novel variants detected in AGT gene among patients with essential hypertension.

    Journal of the renin-angiotensin-aldosterone system : JRAAS·2014
    Same author

    Contribution of REN gene MBbo I polymorphism in conferring risk for essential hypertension: a case control study from South India.

    Journal of the renin-angiotensin-aldosterone system : JRAAS·2012
    Same author

    Estimation of risk and interaction of single nucleotide polymorphisms at angiotensinogen locus causing susceptibility to essential hypertension: a case control study.

    Journal of the renin-angiotensin-aldosterone system : JRAAS·2012
    Same author

    Total activity of glutathione-S-transferase (GST) and polymorphisms of GSTM1 and GSTT1 genes conferring risk for the development of age related cataracts.

    Experimental eye research·2012
    Same author

    Association of shorter telomere length with essential hypertension in Indian population.

    American journal of human biology : the official journal of the Human Biology Council·2012

    Area of Science:

    • Immunology
    • Cardiovascular Medicine
    • Clinical Biochemistry

    Background:

    • Essential hypertension is a complex condition with multifactorial etiology.
    • The role of the immune system in hypertension is an area of ongoing research.
    • Immunoglobulin G (IgG) is a key antibody in humoral immunity.

    Purpose of the Study:

    • To investigate serum IgG levels in patients with essential hypertension.
    • To compare IgG levels between hypertensive cases and normotensive controls.
    • To explore potential associations between IgG levels and hypertension subtypes or characteristics.

    Main Methods:

    • Serum samples were collected from 33 essential hypertensive patients and 30 normotensive controls.
    • Serum IgG concentrations were quantified using a standardized assay.
    • Statistical analyses were performed to compare IgG levels between groups and identify correlations.

    Main Results:

    • Serum IgG levels were significantly elevated in essential hypertensive cases (mean = 2083.87 +/- 99.94 mg/dl) compared to normotensive controls (mean = 993.84 +/- 72.25 mg/dl) (P < 0.001).
    • No significant differences in IgG levels were found between familial and sporadic hypertension, or between males and females.
    • Elevated IgG levels were observed in early-stage hypertension (duration < 1 year).

    Conclusions:

    • The findings support the probable involvement of immunological responses, specifically elevated serum IgG, in essential hypertension.
    • Further research is warranted to elucidate the precise mechanisms linking IgG to hypertension.
    • Serum IgG may serve as a potential biomarker for early-stage essential hypertension.

    Related Experiment Videos