Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemotaxis in experimental syphilis.

K Wicher, C Kalinka, R Belani

    International Archives of Allergy and Applied Immunology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Artificial Intelligence: Guidance for clinical imaging and therapeutic radiography professionals, a summary by the Society of Radiographers AI working group.

    Radiography (London, England : 1995)·2021
    Same author

    ASXL1 and DNMT3A mutation in a cytogenetically normal B3 thymoma.

    Oncogenesis·2014
    Same author

    Effect of Cortisone on the Course of Experimental Syphilis in the Guinea-pig-II: II. ACTION OF CORTISONE WHEN ADMINISTERED IN VARIOUS DOSES AT VARIOUS TIMES TO GUINEA-PIGS PREVIOUSLY INFECTED INTRADERMALLY WITH T. PALLIDUM.

    The British journal of venereal diseases·2011
    Same author

    Pathogenesis of maternal-fetal syphilis revisited.

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2001
    Same author

    Treponema pallidum subsp. pertenue displays pathogenic properties different from those of T. pallidum subsp. pallidum.

    Infection and immunity·2000
    Same author

    Laboratory methods of diagnosis of syphilis for the beginning of the third millennium.

    Microbes and infection·2000
    Same journal

    Epidemiology of the relationship between exposure to indoor allergens and asthma.

    International archives of allergy and applied immunology·1991
    Same journal

    T cells and asthma. II. Regulation of the eosinophilia of asthma by T cell cytokines.

    International archives of allergy and applied immunology·1991
    Same journal

    T cells and asthma. I. Lymphocyte subpopulations and activation in allergic and nonallergic asthma.

    International archives of allergy and applied immunology·1991
    Same journal

    Human upper airway epithelial cell-derived granulocyte-macrophage colony-stimulating factor induces histamine-containing cell differentiation of human progenitor cells.

    International archives of allergy and applied immunology·1991
    Same journal

    Detection of antidrug IgG antibodies in patients with adverse drug reactions to amodiaquine.

    International archives of allergy and applied immunology·1991
    Same journal

    Effects of the platelet-activating factor antagonist BN 52021 on anti-islet cytotoxicity of mononuclear cells and serum from type 1 (insulin-dependent) diabetic patients.

    International archives of allergy and applied immunology·1991
    See all related articles

    Leukocytes from rabbits infected with Treponema pallidum showed increased random motility. While not directly chemotactic, Treponema phagedenis biotype Reiter preparations stimulated leukocyte activity, indicating complex immune responses to syphilis infection.

    Area of Science:

    • Immunology
    • Microbiology
    • Cell Biology

    Background:

    • Syphilis is a complex infectious disease caused by the bacterium Treponema pallidum.
    • Understanding the host immune response, particularly leukocyte behavior, is crucial for developing effective treatments.
    • Leukocyte chemotaxis plays a vital role in immune cell migration to sites of infection.

    Purpose of the Study:

    • To investigate the chemotactic response of peritoneal leukocytes from Treponema pallidum-infected rabbits.
    • To assess the direct chemotactic activity of Treponema species on leukocytes.
    • To evaluate changes in leukocyte motility during the course of infection.

    Main Methods:

    • Peritoneal exudate leukocytes were isolated from normal and T. pallidum-infected rabbits.

    Related Experiment Videos

  • Chemotactic assays were performed using various bacterial and serum-derived chemoattractants.
  • Leukocyte migration was assessed in response to Treponema phagedenis biotype Reiter and T. pallidum preparations.

    • Main Results:

    • Leukocytes from both normal and infected rabbits exhibited robust chemotaxis to standard chemoattractants.
    • Treponema phagedenis biotype Reiter, but not T. pallidum, demonstrated significant chemotactic activity.
    • Rabbits infected for 7 days or longer showed increased random leukocyte motility.

    Conclusions:

    • Leukocyte chemotaxis is generally preserved during T. pallidum infection.
    • Treponema phagedenis biotype Reiter possesses chemoattractant properties not observed with T. pallidum.
    • Increased random motility of leukocytes in later stages of infection suggests altered cellular behavior potentially contributing to pathogenesis or immune evasion.