Multiparametrical approach to fog-challenge-induced bronchial hyperreactivity in asthmatics--protective effects of salbutamol plus beclomethasone dipropionate

A multiparametrical method was used in order to evaluate the characteristics of fog-challenge-induced bronchoreactivity. The effects of the bronchial stimulation were measured by means of spirometrical tests; determination of ventilatory resistances using a new method by interruption and rapid analysis of the expiratory gases, CO2 and He, according to the "multiple single breath" method. The protective efficacy of salbutamol and the salbutamol plus beclomethasone dipropionate combination was evaluated. The results obtained indicate that the combination exerts a greater protective effect, probably related to the stabilizing action of beclomethasone on the bronchial mucosa.