Well-differentiated ovarian Sertoli-Leydig cell tumors: a clinicopathological analysis of 23 cases

Twenty-three well-differentiated Sertoli-Leydig cell tumors of the ovary, which occurred in patients from 18 to 61 years of age (average 34.5 years), are reported. There was definite evidence of androgen production in 40% of the cases and suggestive evidence in an additional 10%. One post-menopausal patient presented because of vaginal bleeding. The tumors were all Stage Iai and ranged from 1.5 to 10 cm (average 5 cm) in diameter. They were typically solid, lobulated, and yellow, yellow-tan, or white. Follow-up of 6 months or more was available for 21 patients. One of them died of breast carcinoma and another of colonic carcinoma without evidence of spread of their ovarian tumor; the remaining 19 were alive and well from 1 to 23 years (average 6 years) postoperatively.