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Adenoid hypertrophy and nasal mucociliary clearance in children. A morphological and functional study
Insights
Children with enlarged adenoids have impaired nasal mucociliary function, unlike those with smaller adenoids who show improvement. This difference is linked to changes in adenoid tissue surface characteristics, impacting nasal clearance in children.
Area of Science:
- Pediatric Otolaryngology
- Respiratory Physiology
Background:
- Nasal mucociliary function is crucial for clearing respiratory secretions.
- Adenoid hypertrophy is common in children and can cause nasal obstruction.
- The relationship between adenoid size, surface characteristics, and mucociliary function requires further investigation.
Purpose of the Study:
- To evaluate nasal mucociliary function and adenoid surface characteristics in children with and without adenoid hypertrophy.
- To compare these parameters with normal adult values.
Main Methods:
- Studied 86 children (4-10 years) divided into groups based on adenoid hypertrophy.
- Assessed nasal mucociliary clearance velocity using the saccharine method.
- Examined adenoid tissue surface morphology via scanning electron microscopy.
Main Results:
- Nasal mucociliary function is generally reduced in children.
- Children with poorly developed adenoids showed progressive improvement, reaching adult levels by age 10.
- Severely hypertrophied adenoids exhibited impaired function without age-related improvement, linked to metaplastic epithelium and cilia loss.
Conclusions:
- Adenoid hypertrophy significantly impairs nasal mucociliary function in children.
- Surface changes in hypertrophied adenoids, including metaplasia and cilia loss, contribute to reduced clearance.
- These findings highlight the impact of adenoid size and associated inflammation on pediatric respiratory health.
Abstract:
The authors have studied nasal mucociliary function and adenoid surface characteristics in a group of 86 children, aged between 4 and 10 years, divided in two groups according to the presence or absence of clinical, instrumental and röntgenographic signs of nasal obstruction due to hypertrophied adenoids. Each group was divided into 3 age-related subgroups (group I: 4-5 years; group II: 6-7 years; group III: 8-10 years). A population of normal adults was chosen both for functional and ultrastructural characteristics. Nasal mucociliary clearance velocity values were evaluated by means of the saccharine method and the surface characteristics of the adenoid tissue by means of scanning electron microscopy. The data obtained show that the nasal mucociliary function is generally reduced in children but, while in the group with poorly developed adenoids an early and progressive improvement can be observed, the children with severely hypertrophied adenoids show an impaired function up to 10 years, without age-related improvements. At almost 10 years, children with poorly developed adenoids reach normal adult clearance values. These functional data can be related to the surface characteristics of adenoid tissue. In fact, while poorly developed adenoids are characterized by a compact layer of ciliated cells, severely hypertrophied adenoids are characterized by a metaplasic epithelium, with almost complete loss of cilia. Such findings, which are probably due to the inflammatory events frequently complicating adenoid hypertrophy, could explain, together with the obstructive effects, the impairment of the nasal mucociliary clearance in childhood.