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Related Experiment Videos

Yohimbine and the model anxiety state.

S A Henauer, H K Gillespie, L E Hollister

    The Journal of Clinical Psychiatry
    |December 1, 1984
    PubMed
    Summary

    Yohimbine hydrochloride was tested as a model for anxiety. While the 60 mg dose showed some anxiety effects and increased blood pressure, it did not reliably induce anxiety compared to placebo.

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    Area of Science:

    • Pharmacology
    • Psychiatry
    • Clinical Trials

    Background:

    • Anxiety disorders are prevalent, necessitating reliable models for research.
    • Yohimbine hydrochloride is an alpha-2 adrenergic antagonist with known sympathomimetic effects.

    Purpose of the Study:

    • To evaluate the efficacy of yohimbine hydrochloride in inducing a "model anxiety state" in human subjects.
    • To assess the dose-dependent effects of yohimbine hydrochloride on anxiety symptoms and physiological parameters.

    Main Methods:

    • A double-blind, placebo-controlled study involving ten healthy subjects.
    • Administration of oral yohimbine hydrochloride at doses of 30 mg and 60 mg, or placebo.
    • Assessment of anxiety using various rating scales and monitoring of blood pressure and pulse rate.

    Main Results:

    • The 60 mg dose of yohimbine hydrochloride showed some evidence of anxiety induction on rating scales.
    • Physiological effects included significant increases in systolic blood pressure and moderate increases in diastolic blood pressure and pulse rate.
    • Anxiety levels induced by the 60 mg dose exceeded placebo in only 50% of the subjects.

    Conclusions:

    • Yohimbine hydrochloride, at the tested doses, does not reliably produce a robust "model anxiety state."
    • The drug elicits physiological changes but lacks consistent anxiogenic effects across individuals.
    • Further research may be needed to explore alternative pharmacological agents or protocols for anxiety modeling.

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