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Related Experiment Videos

Serum imipramine concentrations lower than plasma values.

F J Hullett, A B Levy, K H Tachiki

    The Journal of Clinical Psychiatry
    |December 1, 1984
    PubMed
    Summary
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    Serum imipramine and desipramine levels were significantly lower than plasma levels in patients. This finding highlights the importance of knowing the specific sample type used in laboratory testing for accurate drug monitoring.

    Area of Science:

    • Pharmacology
    • Clinical Chemistry

    Background:

    • Accurate therapeutic drug monitoring (TDM) is crucial for optimizing patient outcomes.
    • Imipramine and its metabolite desipramine are commonly prescribed antidepressants.

    Purpose of the Study:

    • To compare serum and plasma concentrations of imipramine and desipramine.
    • To determine if sample type affects measured drug levels.

    Main Methods:

    • Ten patients receiving imipramine were included.
    • Blood samples were collected in both B-D tiger-top (serum) and green-top (plasma) tubes.
    • Imipramine and desipramine concentrations were measured in both sample types.

    Main Results:

    • Serum concentrations of imipramine and desipramine were significantly lower than plasma concentrations.

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  • This difference was observed consistently across the tested samples.

    • Conclusions:

    • The type of blood collection tube significantly impacts measured imipramine and desipramine levels.
    • Laboratories must clearly indicate whether serum or plasma is used for TDM to ensure accurate interpretation of antidepressant dosing.