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Fatal metoprolol overdose.

M Stajić, R H Granger, J C Beyer

    Journal of Analytical Toxicology
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    This case report details a fatal overdose of metoprolol, a beta-blocker used for hypertension. Postmortem analysis confirmed lethal metoprolol concentrations in various biological samples.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Forensic Science

    Background:

    • Metoprolol is a selective beta-1 adrenergic blocking agent widely prescribed for hypertension.
    • Overdose cases are rare but can lead to severe cardiovascular complications.

    Observation:

    • A case of deliberate metoprolol ingestion resulting in death is presented.
    • Detailed case history and comprehensive postmortem toxicologic findings are documented.

    Findings:

    • High-performance liquid chromatography (HPLC) and gas chromatography/mass spectrometry (GC/MS) were employed for drug identification and quantification.
    • Lethal concentrations of metoprolol were identified in blood (4.7 mg/L), urine (194 mg/L), vitreous humor (3.3 mg/L), pleural fluid (3.9 mg/L), bile (254 mg/L), kidney (7.1 mg/kg), and liver (6.3 mg/kg).

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    Implications:

    • This study highlights the critical importance of analytical toxicology in confirming drug-related fatalities.
    • Understanding toxicokinetic profiles in overdose situations is crucial for clinical and forensic contexts.
    • The findings underscore the potential lethality of metoprolol in massive ingestions.