Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A controllable artificial afterload for isolated heart studies.

A Fisher, R E Challis, P Swann

    Journal of Biomedical Engineering
    |October 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Frustrated and Concerned: Understanding Antipathy Towards Clients Who Engage in Nonsuicidal Self-Injury in Australian Mental Health Practitioners.

    Clinical psychology & psychotherapy·2025
    Same author

    Developing a platform to investigate the heterogeneity of outcomes for patients with ovarian cancer.

    BMJ open quality·2025
    Same author

    Controlling beam trajectory and transport in a tapered helical undulator.

    Journal of synchrotron radiation·2025
    Same author

    The metabolic landscape of tetrahydrobiopterin metabolism disorders in the Republic of Ireland.

    Molecular genetics and metabolism reports·2025
    Same author

    Analysis of substantiated welfare investigations in extensive farming systems in Victoria, Australia.

    Australian veterinary journal·2024
    Same author

    Person-specific and pooled prediction models for binge eating, alcohol use and binge drinking in bulimia nervosa and alcohol use disorder.

    Psychological medicine·2024
    Same journal

    Comparative study of the function of the Abiomed polyurethane heart valve for use in left ventricular assist devices.

    Journal of biomedical engineering·1993
    Same journal

    AZTDIS--a two-phase real-time ECG data compressor.

    Journal of biomedical engineering·1993
    Same journal

    Validation of an automated method of three-dimensional finite element modelling of bone.

    Journal of biomedical engineering·1993
    Same journal

    Three dimensional shape reconstruction and finite element analysis of femur before and after the cementless type of total hip replacement.

    Journal of biomedical engineering·1993
    Same journal

    The Rancho EMG analyzer: a computerized system for gait analysis.

    Journal of biomedical engineering·1993
    Same journal

    Preparation and in vivo evaluation of a newly developed bioglass ceramic.

    Journal of biomedical engineering·1993
    See all related articles

    This study introduces an artificial afterload system for isolated heart research, accurately simulating arterial dynamics. The novel device offers precise control and rapid response, enhancing cardiovascular research capabilities.

    Area of Science:

    • Cardiovascular Physiology
    • Biomedical Engineering
    • Artificial Organ Research

    Background:

    • Isolated heart preparations lack realistic arterial load simulation.
    • Accurate afterload is crucial for studying cardiac function and response.
    • Existing models often fail to replicate dynamic arterial properties.

    Purpose of the Study:

    • To develop and validate a computer-controlled artificial afterload system for isolated heart experiments.
    • To accurately model systemic arterial properties including peripheral resistance, compliance, and impedance.
    • To enable dynamic pressure control and rapid transient response for advanced cardiac research.

    Main Methods:

    • Implementation of the Westerhof model for artificial afterload.
    • Integration of adjustable elements for peripheral resistance and arterial compliance.

    Related Experiment Videos

  • Utilizing feedforward and feedback control techniques for dynamic pressure maintenance.
  • Computerized system for programmable pressure changes and real-time adjustments.

    • Main Results:

    • The system successfully maintained constant arterial pressure despite significant flow variations.
    • Dynamic pressure adjustments were achieved with a recovery and reset time of 3 seconds.
    • Accurate peripheral resistance values were obtainable without direct flow measurement.
    • System stability and rapid transient response were confirmed through testing.

    Conclusions:

    • The developed artificial afterload system provides a robust and accurate tool for isolated heart research.
    • It effectively simulates complex arterial hemodynamics, improving experimental realism.
    • The system's dynamic capabilities and ease of use facilitate advanced cardiovascular investigations.