Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Local immunotherapy for cancer].

T Hattori, M Niimoto, T Toge

    Nihon Geka Gakkai Zasshi
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evaluation of flexible ureteroscope with an omni-directional bending tip, using a JOYSTICK unit (URF-Y0016): an ex-vivo study.

    World journal of urology·2020
    Same author

    Low bilirubin levels are an independent risk factor for diabetic retinopathy and nephropathy in Japanese patients with type 2 diabetes.

    Diabetes & metabolism·2015
    Same author

    A study of the behavior and mechanism of thermal conduction in the skin under moist and dry heat conditions.

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2013
    Same author

    Vildagliptin preserves the mass and function of pancreatic β cells via the developmental regulation and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.

    Diabetes, obesity & metabolism·2012
    Same author

    [An account of a fermented food, "cao," in the daily life of a fishing community: changes of activities for subsistence on "Island B" in the Makassar Straits].

    Tonan Ajia kenkyu·2012
    Same author

    Local suppression of ferroelectricity at PbTiO3 surface steps: a density functional theory study.

    Journal of physics. Condensed matter : an Institute of Physics journal·2012

    Local immunotherapy with OK-432 (a potent immunomodulator) shows promise for cancer treatment. Large doses are effective with minimal side effects, primarily involving immune cell activation and macrophage-driven tumor cell killing.

    Area of Science:

    • Immunology
    • Oncology
    • Pharmacology

    Context:

    • Non-specific cancer immunotherapy often has limited efficacy.
    • Local administration of immunopotentiators may enhance effector cell accumulation at tumor sites.
    • OK-432 has been studied for years as a potential cancer immunotherapy agent.

    Purpose:

    • To evaluate the efficacy and immune cell responses to intratumoral and intraperitoneal administration of large-dose OK-432.
    • To investigate the role of different immune cells in OK-432 mediated cancer immunotherapy.
    • To assess the safety of OK-432, particularly regarding suppressor cell activity.

    Summary:

    • Intratumoral OK-432 administration activates killer T cells and NK cells.
    • Intraperitoneal OK-432 administration leads to sequential infiltration of neutrophils, lymphocytes, and macrophages.

    Related Experiment Videos

  • Macrophages appear crucial for cytostatic activity following intraperitoneal OK-432, with no significant increase in suppressor cells observed.

    • Impact:

    • Large-dose OK-432 demonstrates favorable results with minimal side effects like transient fever.
    • OK-432 immunotherapy effectively mobilizes key immune cells for anti-tumor responses.
    • This study provides evidence for the safety and efficacy of OK-432 in cancer immunotherapy, particularly in gastric cancer patients.