Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[When do I give which antidepressant in the individual case?].

E Fähndrich

    Der Nervenarzt
    |September 1, 1984
    PubMed
    Summary

    Sleep deprivation (SD) can predict antidepressant response. Increased MAO activity after SD suggests Maprotiline effectiveness, while decreased MAO or mood improvement indicates Clomipramine response.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Elevation of plasma 1-deoxy-sphingolipids in type 2 diabetes mellitus: a susceptibility to neuropathy?

    European journal of neurology·2015
    Same author

    Prescribing practices in German and Swiss psychiatric university and in non-university hospitals: national differences.

    International journal of clinical pharmacology and therapeutics·2005
    Same author

    [Family consultation as a part of routine management in a psychiatric and psychotherapy department of the general hospital].

    Psychiatrische Praxis·2001
    Same author

    [Mother-child treatments within the scope of public community psychiatric care. Clinical treatment concept and experiences over 5 years].

    Psychiatrische Praxis·2001
    Same author

    [How do geriatric psychiatry patients evaluate their stay in a specialized psychiatric department of a general hospital?].

    Psychiatrische Praxis·2001
    Same author

    [Depression is by far the most frequent psychiatric disorder].

    Therapeutische Umschau. Revue therapeutique·2000

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Antidepressant drug treatment efficacy varies significantly among patients.
    • Predicting treatment response is crucial for optimizing depression management.
    • Sleep deprivation (SD) has shown potential as a short-term mood elevator and predictor of antidepressant response.

    Purpose of the Study:

    • To investigate the predictive value of sleep deprivation (SD) response and changes in monoamine oxidase (MAO) activity for antidepressant treatment outcomes.
    • To differentiate between predictors for Maprotiline and Clomipramine efficacy.
    • To compare the predictive power of static versus dynamic variables in antidepressant treatment prognosis.

    Main Methods:

    • Assessed the reaction to sleep deprivation (SD) in 60 depressive patients.
    • Measured changes in monoamine oxidase (MAO) activity following SD.
    • Correlated SD response and MAO activity changes with subsequent antidepressant drug treatment (Maprotiline and Clomipramine).
    • Categorized predictor variables into static (e.g., demographics) and dynamic (e.g., SD reaction, mood changes).

    Main Results:

    • Increased MAO activity after SD predicted a positive response to Maprotiline.
    • Decreased MAO activity after SD predicted a positive response to Clomipramine.
    • Mood improvement following SD predicted a positive response to Clomipramine; lack of mood improvement indicated future Maprotiline effectiveness.
    • Dynamic variables demonstrated higher predictive value for treatment success compared to static variables.

    Conclusions:

    • Sleep deprivation response and associated MAO activity changes are valuable dynamic predictors for antidepressant treatment selection.
    • Differentiating between SD reactions allows for tailored prescription of Maprotiline or Clomipramine.
    • Dynamic clinical and biological markers offer superior prognostic capability over static demographic data for antidepressant therapy.

    Related Experiment Videos