Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development and optimization of pharmaceutical formulations using a simplex lattice design.

R Huisman, H V Van Kamp, J W Weyland

    Pharmaceutisch Weekblad. Scientific Edition
    |October 19, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Validation of the Dutch Glasgow Anti- psychotic Side-Effect Scale for Clozapine].

    Tijdschrift voor psychiatrie·2021
    Same author

    A diagnostic tool for self-poisoned patients: Analysis of gastric content and lavage fluids.

    The Netherlands journal of medicine·2020
    Same author

    Influence functions for a hysteretic deformable mirror with a high-density 2D array of actuators.

    Applied optics·2020
    Same author

    Increased podophyllotoxin production in Podophyllum hexandrum cell suspension cultures after feeding coniferyl alcohol as a β-cyclodextrin complex.

    Plant cell reports·2013
    Same author

    Determination of methyldibromoglutaronitrile in cosmetic products by high performance liquid chromatography with electrochemical detection.

    International journal of cosmetic science·2009
    Same author

    Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) microcrystalline cellulose.

    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2004
    Same journal

    Stability and compatibility of four anthracyclines: doxorubicin, epirubicin, daunorubicin and pirarubicin with PVC infusion bags.

    Pharmaceutisch weekblad. Scientific edition·1992
    Same journal

    High pressure liquid chromatographic analysis of the serum concentration of cefuroxime after an intravenous bolus injection of cefuroxime in patients with a coronary artery bypass grafting.

    Pharmaceutisch weekblad. Scientific edition·1992
    Same journal

    Comparison of costs linked to the preparation and administration of fluorouracil as a continuous infusion based on three techniques.

    Pharmaceutisch weekblad. Scientific edition·1992
    Same journal

    Antimicrobial screening of essential oils and extracts of some Humulus lupulus L. cultivars.

    Pharmaceutisch weekblad. Scientific edition·1992
    Same journal

    Administration of oral chloral hydrate to paediatric patients undergoing magnetic resonance imaging.

    Pharmaceutisch weekblad. Scientific edition·1992
    Same journal

    Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport.

    Pharmaceutisch weekblad. Scientific edition·1992
    See all related articles

    Optimizing pharmaceutical formulations using experimental designs and mathematical models significantly reduces trial-and-error time. This approach efficiently identifies optimal drug and excipient compositions by analyzing variable interactions and predicting formulation properties.

    Area of Science:

    • Pharmaceutical Sciences
    • Formulation Development
    • Chemical Engineering

    Background:

    • Traditional pharmaceutical formulation development relies heavily on time-consuming and unreliable trial-and-error methods.
    • Identifying optimal drug and excipient combinations is crucial for effective and stable pharmaceutical products.

    Purpose of the Study:

    • To introduce and demonstrate the utility of experimental mixture designs in optimizing pharmaceutical formulations.
    • To reduce the experimental time and improve the reliability of the formulation development process.

    Main Methods:

    • Utilizing experimental design principles to systematically vary ingredient compositions (independent variables).
    • Employing mathematical models to describe the relationship between composition and formulation properties (dependent variables).

    Related Experiment Videos

  • Analyzing the effects and interactions of different components on the final product characteristics.

    • Main Results:

    • Demonstrated that mixture designs, coupled with mathematical modeling, can efficiently predict formulation responses.
    • Successfully applied the methodology to optimize a tablet formulation composed solely of excipients.
    • Identified optimal compositions that satisfy multiple desired properties simultaneously.

    Conclusions:

    • Experimental mixture designs offer a powerful, systematic approach to pharmaceutical formulation optimization.
    • This methodology significantly enhances efficiency and reliability compared to traditional trial-and-error techniques.
    • Mathematical modeling of formulation responses is key to achieving desired product characteristics.