Effects of beta-neo-endorphin on behaviors in mice using multi-dimensional behavioral analyses

The effect of beta-neo-endorphin on mouse behaviors were examined using multi-dimensional behavioral analyser. The intracerebral injection of beta-neo-endorphin (30 micrograms) decreased the ambulation. However, the decrease in the ambulation was not antagonized by pretreatment with 2 and 4 mg/kg doses of naloxone. These results suggest that the decrease in the ambulation induced by beta-neo-endorphin is not mediated by opioid receptors in the brain.