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Biological activity of new phosphorylated analogues of oxotremorine
Pharmacological Research Communications
|September 1, 1984
Abstract:
A number of N-4 (4-dialkylamino-2-butynyl) phosphoramide derivatives related to the oxotremorine structure were prepared and evaluated for their muscarinic activity on isolated perfused rat hearts. A structure-activity relationship study revealed that among other factors, muscarinic activity is directly related to the environment of the phosphorus atom.