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Hemorrhagic diphtheria.

P Saguanchua, P Patamasucon, S Yuthasompob

    The Southeast Asian Journal of Tropical Medicine and Public Health
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Hemorrhagic diphtheria, a severe form, can cause bleeding and low platelets. Steroid therapy may improve survival in critical diphtheria cases, even with complications like myocarditis.

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    Area of Science:

    • Infectious Diseases
    • Hematology
    • Critical Care Medicine

    Background:

    • Diphtheria is a serious bacterial infection, typically affecting the respiratory tract.
    • Hemorrhagic diphtheria represents a rare and severe manifestation of the disease.
    • Thrombocytopenia, a condition characterized by low platelet counts, can occur in severe infections.

    Observation:

    • Two patients with mild initial symptoms developed sudden bleeding episodes.
    • Both patients presented with clinical signs of diphtheria and severe thrombocytopenia.
    • One patient succumbed to the illness despite standard treatment, while the other survived.

    Findings:

    • Hemorrhagic diphtheria is associated with severe thrombocytopenia.
    • Standard antitoxin, antibiotic, and supportive care were insufficient in one fatal case.

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  • Adjunctive steroid therapy in the second case was associated with survival and development of diphtheria myocarditis.

    • Implications:

    • Early recognition and aggressive management are crucial for hemorrhagic diphtheria.
    • The role of steroid therapy in severe diphtheria warrants further investigation.
    • Understanding the link between diphtheria, thrombocytopenia, and myocarditis is vital for patient outcomes.