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Minimal deviation melanoma.

L H Barr, L I Goldman, J A Solomon

    Surgery, Gynecology & Obstetrics
    |December 1, 1984
    PubMed
    Summary
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    Minimal deviation melanoma (MDM) appears to have a low likelihood of aggressive behavior, even with significant tumor thickness. Radical surgical therapy may be unnecessary for these cases, suggesting a need for revised prognostic criteria.

    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Minimal deviation melanoma (MDM) is a recently described entity with unclear biological significance.
    • Minimally deviant melanocytes are not observed in metastases, suggesting a different biological behavior compared to overtly malignant cells.
    • Traditional prognostic criteria like Breslow depth and Clark's level may not be applicable to MDM.

    Purpose of the Study:

    • To evaluate the clinical behavior and appropriate treatment for minimal deviation melanoma.
    • To determine if standard prognostic criteria are relevant for MDM.
    • To assess the risk of recurrence and metastasis in MDM patients.

    Main Methods:

    • Retrospective case series of eight patients diagnosed with minimal deviation melanoma.

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  • All patients underwent scar re-excision and primary closure.
  • Tumor characteristics including thickness (0.31-1.65 mm) and Clark's level (up to IV) were recorded.

    • Main Results:

    • Median follow-up was 19 months.
    • No local recurrence or distant metastasis was observed in any of the eight patients.
    • Tumor thickness and Clark's level did not correlate with aggressive behavior in this cohort.

    Conclusions:

    • Minimal deviation melanoma exhibits a low likelihood of aggressive behavior, despite features that might suggest otherwise.
    • Radical surgical therapy appears unnecessary for MDM.
    • Further research is needed to refine prognostic criteria for MDM.