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Related Experiment Videos

Melting corneas with collapsing nose.

J B Michelson

    Survey of Ophthalmology
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Relapsing polychondritis can cause severe eye inflammation, including corneal melting. Chlorambucil effectively treated refractory ocular inflammation in a patient with this rare autoimmune disease.

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    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Autoimmune Diseases

    Background:

    • Relapsing polychondritis is a rare systemic autoimmune disorder characterized by progressive inflammation and destruction of cartilaginous tissues.
    • Ocular manifestations of relapsing polychondritis, such as episcleritis and keratitis, can be severe and vision-threatening.

    Observation:

    • A 31-year-old woman with relapsing polychondritis presented with severe episcleritis, conjunctival chemosis, and corneal inflammation with melting.
    • The ocular inflammation was refractory to conventional corticosteroid therapy.

    Findings:

    • Initiation of chlorambucil, an immunosuppressive agent, led to significant subsidence of ocular inflammation.
    • The patient's eye examination returned to near-normal status after chlorambucil treatment.

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  • Associated inflammation of nasal and ear cartilage supported the diagnosis of relapsing polychondritis.

    • Implications:

    • Chlorambucil represents a viable therapeutic option for managing severe, refractory ocular inflammation in relapsing polychondritis.
    • Early diagnosis and aggressive immunosuppressive therapy are crucial for preventing vision loss in patients with ocular involvement of relapsing polychondritis.
    • This case highlights the importance of considering systemic autoimmune diseases in patients with severe, unexplained ocular inflammatory conditions.