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Related Experiment Videos

Androgen receptors in human thyroid tissue.

R A Prinz, L Sandberg, P K Chaudhuri

    Surgery
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Androgen receptors were found in human thyroid tumors, suggesting that androgens may influence thyroid tumor growth. This study analyzed receptor distribution in various thyroid tissues from 31 patients.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Molecular Biology

    Background:

    • Androgens are known to influence various cellular processes.
    • The role of androgens in thyroid tumor development is not well understood.

    Purpose of the Study:

    • To investigate the presence and characteristics of androgen receptors in human thyroid tumors.
    • To evaluate the potential influence of androgens on thyroid tumor growth.

    Main Methods:

    • Analysis of cytosolic androgen receptors in thyroidectomy specimens from 31 patients.
    • Utilized protamine sulfate precipitation and Scatchard analysis.
    • Sucrose density gradient analysis for selected specimens.

    Main Results:

    • Seventeen of 31 specimens tested positive for androgen receptors.

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  • Positive specimens showed high-affinity, saturable receptors similar to other androgen-dependent tissues.
  • Androgen receptors were detected in papillary carcinomas, follicular adenomas, and benign thyroid tissues.

    • Conclusions:

    • The presence of androgen receptors in thyroid tumors suggests a potential role for androgens in their growth.
    • Physiological androgen levels may influence the development or progression of thyroid tumors.