[Impairment of protein biosynthesis in the spinal cord in ischemia and recirculation]

Polysomic profiles and ultrastructure of granulated endoplasmic reticulum of the dog spinal cord as well as incorporation of labelled amino acids to cytosol proteins during ischemia and recirculation are studied. Ischemia does not evoke serious changes of the studied parameters while several minutes after ligature removal there appear pronounced changes in the ribosome distribution confirmed by electron-microscopic examination. Complete restoration of the observed parameters after the induced ischemia requires two days.