[Histomorphologic studies of prostate biopsies, prostatectomy preparations and lymph node metastases in prostatic...

Histomorphological studies on 40 prostatectomy and 122 lymphadenectomy preparations from patients with carcinoma of the prostate revealed the limits of prostate biopsy in assessing the volume of the tumour preoperatively, of capsule infiltration and of tumour histology in general. Multiple foci, the exclusion of dedifferentiated portions of a tumour and the lack of correlation between the histology of primary tumours and the degree of lymphogenous metastasis are limiting factors in the individual use of the histology of primary tumours for grading purposes. Our studies furthermore revealed the necessity for differentiated consideration of the category T3 and for intraoperative microscopic examination of resection margins in total prostatavesiculectomy.