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[Prolactin-producing hypophyseal adenomas].

M Sas, E Pásztor, G Godó

    Zentralblatt Fur Gynakologie
    |January 1, 1984
    PubMed
    Summary
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    This study reports on 10 women with hyperprolactinemia due to pituitary microadenomas. Treatment involved surgery or long-term bromocriptine, leading to decreased galactorrhea and restored ovulation.

    Area of Science:

    • Endocrinology
    • Neurosurgery

    Background:

    • Hyperprolactinemia is often caused by pituitary microadenomas.
    • Diagnosis requires clinical, hormonal, and neuroradiological evaluation.

    Purpose of the Study:

    • To report the diagnosis and therapy of 10 women with hyperprolactinemia caused by pituitary microadenomas.
    • To evaluate treatment outcomes for surgical versus medical management.

    Main Methods:

    • Diagnosis based on clinical symptoms, hormonal assays, and neuroradiological imaging.
    • Surgical treatment via transsphenoidal route in six patients.
    • Long-term bromocriptine therapy for three patients and one patient refusing surgery.

    Main Results:

    • Post-surgical outcomes included decreased galactorrhea and restored ovulatory cycles in all cases.

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  • Bromocriptine therapy also led to symptom improvement and ovulation.
  • Long-term bromocriptine may further improve outcomes and resolve residual complaints.

    • Conclusions:

    • Transsphenoidal surgery is effective for pituitary microadenomas causing hyperprolactinemia.
    • Long-term bromocriptine therapy is a viable alternative, especially when surgery is not indicated or refused.
    • Comprehensive management, potentially including prolonged bromocriptine, can optimize patient outcomes.