Levels of complement factors and immunoglobulins in asthmatic children undergoing hyposensitization

We have studied the levels of IgG, IgE, IgM, IgA, total complementary activity, C3, Factor B, C4 components and rheumatoid factor in healthy and asthmatic children before, during and after seven months of hyposensitization treatment to house dust. The IgE, IgM, IgG, C3, Bf and C4 were found to be increased in the asthmatic group before the treatment, with regard to the healthy children. The results obtained from the asthmatic children before treatment and the same subjects after seven months of hyposensitization, suggest that immunotherapy produces a significant increase of IgA, total complementary activity, and also a significant reduction of IgM, IgG and C4. No positive rheumatoid factor was found in the serum of patients undergoing hyposensitization.