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Genetic causes of chronic musculoskeletal disease in childhood are common

D Gregory, P Kaplan, C R Scriver

    American Journal of Medical Genetics
    |November 1, 1984
    PubMed

    Insights

    Genetic causes of pediatric musculoskeletal diseases increased significantly after polio immunization. This highlights the growing importance of genetic factors in orthopedic care and staff education.

    Area of Science:

    • Pediatric Orthopedics
    • Medical Genetics
    • Epidemiology

    Background:

    • Poliomyelitis was a major cause of pediatric musculoskeletal disease.
    • Universal immunization against poliomyelitis has dramatically reduced its incidence.

    Purpose of the Study:

    • To compare the causes of pediatric orthopedic admissions between the polio era and the post-polio era.
    • To assess the changing relative importance of genetic versus non-genetic causes of musculoskeletal disease.

    Main Methods:

    • Retrospective analysis of hospital admissions for pediatric orthopedics.
    • Comparison of admission data from 1957 (polio era) and 1982 (post-polio era).

    Main Results:

    • Admissions for genetic musculoskeletal diseases rose from 45% in 1957 to 57% in 1982 (p < 0.02).
    • Admissions for non-genetic musculoskeletal diseases decreased from 44% in 1957 to 28% in 1982 (p < 0.001).

    Conclusions:

    • The prevalence of genetic causes for pediatric musculoskeletal conditions has increased.
    • Genetics plays a crucial role in pediatric orthopedic services and staff training.

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