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Related Experiment Videos

Factor XI deficiency: detection and management during urological surgery.

A Sidi, U Seligsohn, P Jonas

    The Journal of Urology
    |April 1, 1978
    PubMed
    Summary

    Hereditary factor XI deficiency often goes undiagnosed until bleeding occurs. Screening urological patients identified 10 new cases, highlighting the need for pre-operative partial thromboplastin time testing in Ashkenazic Jews.

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    Abnormal plasma clot structure and stability distinguish bleeding risk in patients with severe factor XI deficiency.

    Journal of thrombosis and haemostasis : JTH·2014

    Area of Science:

    • Hematology
    • Genetics
    • Urology

    Background:

    • Hereditary factor XI deficiency can lead to severe bleeding, often diagnosed post-operatively or post-trauma.
    • A screening protocol for coagulation disorders was implemented for urological patients.

    Observation:

    • Over two years, 10 additional cases of factor XI deficiency were identified (5 severe, 5 partial).
    • All identified patients were Ashkenazic Jews of Eastern European descent.
    • Severe deficiency cases undergoing surgery had no complications with fresh frozen plasma transfusions.

    Findings:

    • Partial factor XI deficiency cases experienced post-operative bleeding without transfusions.
    • A minimum factor XI level of 0.3 U./ml. (30%) is crucial for adequate hemostasis during surgery.

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  • High gene frequency of factor XI deficiency exists in the Ashkenazic Jewish population.

    • Implications:

    • Pre-operative partial thromboplastin time screening is recommended for Ashkenazic Jewish patients requiring surgery.
    • Early detection and management of factor XI deficiency can prevent surgical complications.
    • This study underscores the importance of population-specific genetic screening for bleeding disorders.