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Trimethoprim resistance plasmids.

S G Amyes, I M Gould

    Annales De Microbiologie
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Trimethoprim resistance in enterobacteria decreased when trimethoprim (Tp) was prioritized for urinary tract infections. Continued antimicrobial therapy correlated with persistent trimethoprim-resistant (Tp-R) strains, which resolved upon cessation of treatment.

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    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Enterobacteria carrying resistance plasmids pose a significant challenge in hospital settings.
    • Trimethoprim (Tp) resistance, often plasmid-mediated, impacts treatment efficacy for bacterial infections.

    Purpose of the Study:

    • To investigate the prevalence of trimethoprim resistance in enterobacteria within a general hospital.
    • To assess the impact of changing treatment strategies on the incidence of trimethoprim resistance plasmids (R-plasmids).

    Main Methods:

    • Survey of 320 patients in medical wards over a 6-month period.
    • Identification of enterobacteria harboring resistance plasmids conferring trimethoprim resistance.
    • Correlation of antimicrobial therapy patterns with the prevalence of Tp-resistant strains.

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    Main Results:

    • Initially, 5.6% of patients harbored enterobacteria with trimethoprim resistance plasmids (R-plasmids).
    • When trimethoprim (Tp) became the first-choice treatment for urinary tract infections, the incidence of Tp-R-plasmid strains decreased to 4%.
    • Persistent antimicrobial therapy was associated with the continued presence of Tp-R-plasmid strains in the gut.

    Conclusions:

    • Strategic use of trimethoprim can reduce the prevalence of trimethoprim-resistant enterobacteria.
    • Antimicrobial stewardship is crucial, as continuous therapy promotes the persistence of resistant strains.
    • Discontinuation of antimicrobial therapy facilitates the clearance of trimethoprim-resistant organisms.