HLA antigens in nickel allergy

HLA-A, B and C antigens were determined in 38 and HLA-DR and MT antigens in 30 patients with nickel allergy. The prevalence of B12 was increased (p less than 0.007) and that of DR1 decreased (p less than 0.02). Although these deviations are statistically significant, it is more likely that they are only coincidental and not an evidence of a real association between HLA and nickel allergy. This data, as in earlier reports does not indicate significant associations between HLA antigens and nickel allergy.