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Related Experiment Videos

False-positive complement-fixation serology in histoplasmosis. A retrospective study.

P B Terry, E C Rosenow, G D Roberts

    JAMA
    |June 9, 1978
    PubMed
    Summary

    A significant portion of positive histoplasmosis serology tests yield false positives. These results, particularly high complement-fixation titers, often lack clinical or laboratory correlation with active infection.

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    Area of Science:

    • Medical Mycology
    • Clinical Serology
    • Infectious Diseases

    Background:

    • Histoplasmosis diagnosis relies on serological tests like immunodiffusion and complement-fixation.
    • Interpreting these serological results requires careful consideration of clinical context.

    Purpose of the Study:

    • To evaluate the clinical significance of positive histoplasmosis serologic tests.
    • To determine the incidence and characteristics of false-positive serologic results in patients.

    Main Methods:

    • Retrospective review of 79 patients with positive histoplasmosis immunodiffusion or complement-fixation tests.
    • Analysis of clinical and laboratory data to assess infection evidence.
    • Comparison with complement-fixation titers in a normal patient population.

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    Main Results:

    • 28% (35%) of patients with positive serology showed false-positive results.
    • 12% (15%) had high complement-fixation titers (≥1:32) without evidence of active infection.
    • No specific clinical or laboratory finding correlated with false-positive tests.

    Conclusions:

    • Positive histoplasmosis serology, especially high complement-fixation titers, may not indicate active infection.
    • False-positive serologic results are common and their incidence aligns with that in the general population.