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Treatment of typhoid fever with cefamandole
Antimicrobial Agents and Chemotherapy
|September 1, 1984
Abstract:
Cefamandole therapy was evaluated in nine patients with typhoid fever. Six patients, including all five who received the antibiotic by continuous intravenous drip (8.0 g daily), were cured. Dosage schedules resulting in maintenance of antibiotic concentrations in serum high above the MIC seemed to correlate well with treatment success.
Insights
Cefamandole effectively treated typhoid fever in most patients. Continuous intravenous administration of this antibiotic at 8.0 g daily led to successful outcomes, suggesting high serum concentrations are key for treatment success.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Typhoid fever remains a significant global health concern.
- Effective antibiotic therapies are crucial for managing Salmonella Typhi infections.
- Understanding optimal dosing strategies for antibiotics like cefamandole is important.
Purpose of the Study:
- To evaluate the efficacy of cefamandole in treating typhoid fever.
- To determine the correlation between cefamandole dosage, serum concentrations, and treatment outcomes.
Main Methods:
- A clinical study involving nine patients diagnosed with typhoid fever.
- Administration of cefamandole via different schedules, including continuous intravenous drip.
- Monitoring of patient recovery and serum antibiotic concentrations relative to the Minimum Inhibitory Concentration (MIC).
Main Results:
- Six out of nine patients with typhoid fever were successfully treated with cefamandole.
- All five patients receiving continuous intravenous cefamandole at 8.0 g daily achieved a cure.
- Higher serum cefamandole concentrations above the MIC correlated with successful treatment.
Conclusions:
- Cefamandole is a viable therapeutic option for typhoid fever.
- Continuous intravenous administration of cefamandole at high doses (8.0 g daily) demonstrates significant efficacy.
- Maintaining antibiotic serum levels substantially above the MIC is critical for successful typhoid fever treatment with cefamandole.