Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin E and dapsone-induced hemolysis.

J W Kelly, J Scott, M Sandland

    Archives of Dermatology
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of intracoronary saline infusion on dissection during excimer laser coronary angioplasty: a randomized trial. The Percutaneous Excimer Laser Coronary Angioplasty (PELCA) Investigators.

    Journal of the American College of Cardiology·1995
    Same author

    Desmoplastic trichoepithelioma of the upper lip. A case report with histochemical features and observations on its histogenesis.

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·1995
    Same author

    Survival, metastasis and recurrence of oral cancer in relation to pathological features.

    Annals of the Royal College of Surgeons of England·1995
    Same author

    Psychological treatments for depression. An update.

    The British journal of psychiatry : the journal of mental science·1995
    Same author

    Microsomal triglyceride transfer protein activity remains unchanged in rat livers under conditions of altered very-low-density lipoprotein secretion.

    The Biochemical journal·1995
    Same author

    School's out ... for family planning.

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)·1995

    Vitamin E did not significantly reduce dapsone-induced hemolysis in patients. Hemoglobin and reticulocyte counts remained unchanged, indicating vitamin E is not a substantial treatment for this side effect.

    Area of Science:

    • Pharmacology
    • Hematology
    • Nutritional Science

    Background:

    • Dapsone is a medication known to cause hemolysis (red blood cell destruction).
    • Vitamin E (dl-alpha tocopherol acetate) is an antioxidant that has been investigated for potential protective effects against oxidative stress.

    Purpose of the Study:

    • To investigate whether Vitamin E supplementation can ameliorate dapsone-induced hemolysis.
    • To assess the impact of Vitamin E on key hematological markers in patients receiving dapsone.

    Main Methods:

    • Sixteen patients receiving 100 mg/day of dapsone were studied.
    • Vitamin E (800 mg/day) was administered for up to three months while dapsone therapy continued.
    • Hemolysis parameters including hemoglobin, reticulocyte count, haptoglobin, and erythrocyte survival were measured.

    Related Experiment Videos

    Main Results:

    • Vitamin E supplementation significantly increased serum vitamin E levels.
    • No substantial changes were observed in hemoglobin, reticulocyte count, or haptoglobin levels.
    • Erythrocyte survival showed no significant change.
    • Erythrocyte Heinz body count decreased in most patients, but overall hemolysis was not substantially reduced.

    Conclusions:

    • Vitamin E therapy at 800 mg/day does not substantially mitigate the hemolytic effects of dapsone at 100 mg/day.
    • While some markers like Heinz body count may be affected, Vitamin E is not a significant treatment for dapsone-induced hemolysis.