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Salmonella meningitis in infancy.

L C Low, B C Lam, W T Wong

    Australian Paediatric Journal
    |August 1, 1984
    PubMed
    Summary
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    High mortality and morbidity were observed in Salmonella meningitis cases despite treatment. Chloramphenicol is not recommended; bactericidal antibiotics like moxalactam for 4-6 weeks, potentially with intraventricular administration, are advised for Salmonella meningitis.

    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Neurology

    Background:

    • Salmonella meningitis presents a significant challenge with high mortality and morbidity.
    • Previous treatment strategies may be suboptimal due to the nature of the causative agent.

    Purpose of the Study:

    • To evaluate treatment outcomes for Salmonella meningitis.
    • To identify more effective antibiotic strategies for Salmonella meningitis.

    Main Methods:

    • Retrospective case series analysis of 13 patients with Salmonella meningitis.
    • Review of antibiotic efficacy and treatment durations.

    Main Results:

    • High mortality and morbidity rates were observed in the studied cases.
    • Chloramphenicol demonstrated bacteriostatic effects, deeming it unsuitable.

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  • Extended treatment (4-6 weeks) with bactericidal antibiotics is suggested.

    • Conclusions:

    • Chloramphenicol is not recommended for Salmonella meningitis due to its bacteriostatic action.
    • Bactericidal antibiotics achieving adequate cerebrospinal fluid concentrations, such as moxalactam, are preferred.
    • Intraventricular therapy should be considered for persistent infections.