Inhibition of carrageenan edema formation by organotin compounds

The effects of a single p.o. dose of 0.3-10 mg/kg of organotin compounds such as dibutyltin dichloride (Bu2SnCl2) and triphenyltin chloride (Ph3SnCl) on the development of edema after subplantar injection of 0.5 mg of carrageenan in 0.05 ml of pyrogen-free saline were examined as compared with those of hydrocortisone. Bu2SnCl2, Ph3SnCl and hydrocortisone did not significantly inhibit the development of the first phase of edema at any dose level, but produced more than 90, 70 and 90% inhibition of the second phase, respectively, at a dose of 10 mg/kg 1 hr before the irritant. Moreover, these inhibitions of the second phase were dose-dependent.