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[Mesenteric microvessel reactivity in rats in mesenteric shock].

J Hamar, L Deji, V I Udovichenko

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |November 1, 1984
    PubMed
    Summary

    Mesenteric shock in rats involves two phases of microvascular reactivity changes. Initially, sensitivity to adrenaline increases, then decreases, explaining late-stage vasodilation.

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    Area of Science:

    • Physiology
    • Pharmacology
    • Pathophysiology

    Context:

    • Mesenteric shock is a critical condition affecting microvascular function.
    • Understanding microvascular reactivity is crucial for managing shock states.

    Purpose:

    • To investigate the biphasic changes in rat mesenteric microvessel reactivity during shock.
    • To elucidate the mechanisms underlying vasodilation in late-stage mesenteric shock.

    Summary:

    • Mesenteric shock development in rats exhibits two distinct phases of microvascular reactivity.
    • Initial shock phase shows increased microvessel sensitivity to adrenaline, followed by a decrease.
    • Late-stage vasodilation is attributed to reduced catecholamine levels and diminished microvessel sensitivity.

    Impact:

    • Provides mechanistic insights into steady vasodilation during mesenteric shock.
    • Explains the response to exogenous adrenaline and noradrenaline in shock.
    • Informs potential therapeutic strategies targeting microvascular dysfunction in shock.

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