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Steroid receptors in human meningioma
Clinical Neuropharmacology
|January 1, 1984
Summary
This study found progesterone receptors (PR) in most meningioma tumors, suggesting hormone therapy may be an option for difficult-to-treat cases. Estrogen receptors (ER) were not detected in these brain tumors.
Area of Science:
- Neuro-oncology
- Endocrinology
- Pathology
Background:
- Meningiomas are more common in women and can progress rapidly during pregnancy.
- Steroid hormone receptors have been detected in human meningiomas.
- Understanding receptor status is crucial for potential therapeutic strategies.
Purpose of the Study:
- To investigate the presence and levels of estrogen receptors (ER) and progesterone receptors (PR) in meningioma tissue.
- To explore potential correlations between receptor status and patient demographics or tumor characteristics.
Main Methods:
- Radioreceptor assays using a dextran-coated charcoal procedure were employed.
- Flat-bed isoelectric focusing in agarose gel was used for confirmation.
- Twenty-two cases of meningioma were analyzed.
Main Results:
- Specific estrogen receptors (ER) were not detected in any of the meningioma samples.
- Specific progesterone receptors (PR) were found in 17 out of 22 meningiomas (77%).
- PR levels ranged from 11-314 fmol/mg cytosol protein.
Conclusions:
- The high prevalence of progesterone receptors (PR) in meningiomas suggests a potential role for hormone therapy.
- PR status did not correlate with patient age, sex, or tumor site.
- PR negativity was observed in aggressive subtypes like angioblastic meningiomas.