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Mesor-hypertension: hints by chronobiologists.

F Carandente, A Ahlgren, F Halberg

    Chronobiologia
    |July 1, 1984
    PubMed
    Summary
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    Circadian rhythms in cardiovascular parameters persist even with beta-blocker use. Continuous monitoring reveals that penbutolol does not eliminate these vital physiological variations, maintaining healthy blood pressure patterns.

    Area of Science:

    • Cardiology
    • Chronobiology
    • Physiology

    Background:

    • Circadian and ultradian rhythms are crucial in cardiovascular pathophysiology.
    • Key cardiovascular parameters like heart rate and blood pressure exhibit daily patterns.
    • Accurate blood pressure assessment requires prolonged monitoring, not single measurements.

    Purpose of the Study:

    • To investigate the effect of the beta-blocker penbutolol on circadian rhythms of cardiovascular parameters.
    • To determine if penbutolol administration eliminates physiological circadian variations in blood pressure and heart rate.
    • To assess the impact of penbutolol on cardiovascular rhythms using continuous monitoring.

    Main Methods:

    • Utilized automatic and continuous monitoring of cardiovascular parameters over extended periods (at least 48 hours).

    Related Experiment Videos

  • Analyzed circadian and ultradian rhythms in heart rate, arterial pressure, and other relevant metrics.
  • Quantified cardiovascular parameter variations and identified potential phase shifts or amplitude changes.

    • Main Results:

    • Penbutolol administration did not eliminate the physiological circadian variations in cardiovascular parameters.
    • Continuous monitoring showed prominent amplitudes in cardiovascular rhythms during penbutolol treatment.
    • A significant phase shift (approx. 100 degrees delay) in heart rate was observed in one patient.

    Conclusions:

    • The beta-blocker penbutolol preserves normal circadian variations in cardiovascular function.
    • Continuous monitoring is essential for understanding the impact of medications on cardiovascular rhythms.
    • Elimination of circadian rhythms is not observed with penbutolol, suggesting preserved physiological regulation.