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Related Experiment Videos

Startle-induced epileptic seizures.

U Aguglia, P Tinuper, H Gastaut

    Epilepsia
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Startle-induced epilepsy, a rare reflex epilepsy, was studied in 16 patients. Clobazam demonstrated significant effectiveness in controlling seizures with minimal side effects, offering a promising treatment option.

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    Area of Science:

    • Neurology
    • Epileptology
    • Clinical Neurophysiology

    Background:

    • Startle-induced epilepsy is a rare reflex epilepsy with limited treatment options.
    • Benzodiazepines are explored for their therapeutic potential in managing this condition.

    Purpose of the Study:

    • To describe 16 additional patients with startle-induced epileptic seizures.
    • To further clarify the therapeutic activity of benzodiazepines, specifically clobazam, in this rare epilepsy.

    Main Methods:

    • Detailed electroclinical data (interictal and ictal) were collected from 16 pediatric patients.
    • CT-scans were performed on 10 patients, with six showing mesial hemispheric atrophy.
    • Benzodiazepines (clonazepam and clobazam) were added to existing antiepileptic treatments.

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    Main Results:

    • Clobazam was administered to 13 patients, achieving good seizure control in 61.5% (mean 22.75 months) with a 91.5% reduction in seizures.
    • Clonazepam showed limited efficacy, with only two of three patients achieving seizure freedom.
    • Few unfavorable side effects were noted with clobazam, and some favorable effects like "psychomotor arousal" were observed.

    Conclusions:

    • Clobazam is an important therapeutic option for startle epilepsy, offering significant seizure reduction.
    • Despite potential loss of efficacy over time, clobazam's favorable side effect profile makes it valuable.
    • Further research into benzodiazepine efficacy in reflex epilepsies is warranted.